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The most commonly reported side effects for both agents are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

The two outcomes compound in a way that makes the effort and cost of running both compounds worthwhile compared to running either alone

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If they are present, flick the barrel of the syringe gently until the bubbles rise to the top, then push them out carefully before withdrawing the needle